¹⁸ F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt–Jakob disease: a case report

Zhuoying Zhu; Qing Huang; Sheng Chen; Qinming Zhou

doi:10.1136/bmjno-2025-001465

January 1, 2026BMJ Neurology OpenOpen Access

¹⁸ F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt–Jakob disease: a case report

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Key Points

Findings indicate early and widespread neuroinflammation using PET/MRI in the patient.
The case highlights the potential of F-DPA-714 PET for better diagnostic sensitivity than conventional MRI.
Evaluation employed a PET/MRI technique unique to sporadic Creutzfeldt–Jakob Disease assessment.
This suggests the need for further research on diagnostic implications in similar neurodegenerative conditions.

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Implication

Case report reveals early neuroinflammation in sporadic Creutzfeldt–Jakob Disease, suggesting improved diagnosis.

Abstract

This is the first reported case of sCJD evaluated with ¹⁸F-DPA-714 PET/MRI. The findings suggest that ¹⁸F-DPA-714 PET/MRI may provide complementary sensitivity beyond structural MRI, potentially improving early diagnostic confidence in sCJD.

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Zhu et al. (2026) studied this question.

synapsesocial.com/papers/69a75c7ac6e9836116a25645 https://doi.org/10.1136/bmjno-2025-001465

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¹⁸ F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt–Jakob disease: a case report

Key Points

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Implication

Abstract

Discussion

Cite This Study

¹⁸ F-DPA-714 PET/MRI reveals early and widespread neuroinflammation in sporadic Creutzfeldt–Jakob disease: a case report

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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