Formal Total Synthesis of Daphnenoid A

Key Points

• Daphnenoid A synthesis reveals stronger anti-inflammation activities in certain intermediates compared to the original compound.
• The minimal change in stereocenter configuration notably influenced chemoselectivity in the synthesis process.
• The methodology incorporates a crucial Morita-Baylis-Hillman reaction followed by a key intramolecular Diels-Alder reaction.
• Findings may highlight novel therapeutic applications for synthesized intermediates in inflammation-related conditions.