Observational analysis emphasizes the need for prospective validation of the Padua D-dimer score, suggesting collaboration on future studies.
To the Editor: We thank Dr Vijayasimha and colleagues for their thoughtful analysis of our work and their proposal for prospective validation of the Padua × D-dimer (PaDd) score. Their roadmap provides a rigorous framework that addresses critical gaps in our single-center retrospective design. We welcome this opportunity to clarify key methodological considerations and invite the global research community to collaborate on next-generation studies.
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Cohen et al. (2026) studied this question.
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