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March 3, 2026Frontiers in Immunology0 citationsOpen Access

Prognostic impact of advanced lung cancer inflammation index and tumor load index in esophageal squamous cell carcinoma after neoadjuvant immunochemotherapy

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YHYizhou HuangMCMaohui ChenZYZhenyuan Yang

Key Points

  • Low lung cancer inflammation index combined with high tumor load identifies aggressive esophageal squamous cell carcinoma cases, leading to poor survival.
  • The study indicates that this combined index can help tailor risk-adapted treatment strategies for better outcomes in esophageal cancer patients.
  • Integration of the lung cancer inflammation index and tumor load index shows strong prognostic value for patient management after neoadjuvant immunochemotherapy.
  • This analysis highlights the need for personalized treatment plans based on individual tumor characteristics for managing esophageal squamous cell carcinoma.

Abstract

Pre-treatment ALI and TL jointly provide robust and complementary prognostic information in ESCC patients receiving neoadjuvant immunochemotherapy. Low ALI combined with high TL identifies a biologically aggressive subset with poor pathologic response and inferior survival. Integration of ALI and TL may facilitate risk-adapted perioperative strategies and personalized treatment optimization.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69a75cacc6e9836116a25bddhttps://doi.org/10.3389/fimmu.2026.1724061
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