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January 28, 2026Pharmacology Biochemistry and Behavior

Protocadherin 10, a member of cadherin superfamily, increases stress-susceptibility in chronic unpredictable stress-treated rats

Xin-Mu Li Ningning Zhang Xi Zhang Nuo Liu Cong-Yuan Xia Yao Xiong Huiqin Wang Yan Xu Shi-Feng Chu Nai‐Hong Chen Zi Wang

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Key Points

Increased stress-susceptibility is associated with higher levels of protocadherin 10 in rats.
The study indicates that chronic unpredictable stress affects protocadherin levels, influencing behavior.
Experiments involved monitoring chronic unpredictable stress responses in rat models and their behavior changes.
These results suggest the potential for targeting protocadherin 10 in understanding stress-related disorders, though limits exist in rodent models.

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Implication

Observational analysis reveals increased stress-susceptibility linked to protocadherin 10 in rats, highlighting its role in stress response.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69a75cbac6e9836116a25dbd https://doi.org/10.1016/j.pbb.2026.174158

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