Validation of the European SCORE2 algorithm in one European and one Latin-American cohort studies with contrasting populations
Key Points
SCORE2's prediction of cardiovascular disease showed varied accuracy between cohorts, with recalibration needed for the Portuguese group.
It performed adequately in the Mexican cohort, indicating population-specific factors influence risk prediction.
Analysis across two contrasting populations highlights the importance of local adjustments to prediction algorithms.
Recalibration may enhance SCORE2's effectiveness in diverse populations, addressing disparities in cardiovascular risk assessment.
Abstract
SCORE2 estimates modest to acceptable performance for predicting the 10-year CVD in Mexicans but performed less favourably in the Portuguese cohort, indicating a need for recalibration.