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Observational analysis reveals distinct female-specific knee osteoarthritis features, highlighting necessary treatment considerations.
Our findings uncover a distinct female-specific musculoskeletal phenotype in early-stage KOA, characterized by muscle degeneration and cartilage deterioration undetectable by radiography. These female-specific clinical manifestations may be due, at least partly, to aberrant adipogenic programming in muscle. These findings provide mechanistic and clinical insight into sexual dimorphism in KOA.
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Hoki et al. (2026) studied this question.
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