Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

Yi-Fan Miao; Jiaqi Yao; Yang Peng; Ding Bai; Shu-han Fan; Hong-ying Li; Wei Jin; Yun Lu

doi:10.1016/j.joim.2026.01.007

January 1, 2026Journal of Integrative MedicineOpen Access

Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

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Key Points

Honokiol restores mitochondrial oxidative phosphorylation, enhancing cellular energy production.
SIRT3 activation leads to the deacetylation of CYC1, a key component in mitochondrial function.
Analysis demonstrates that increased SIRT3 activity alleviates hyperacetylation during acute pancreatitis.
Implications highlight the potential of honokiol as a therapeutic agent in managing pancreatic inflammatory conditions.

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Implication

Observational analysis reveals honokiol's role in restoring mitochondrial function in acute pancreatitis, suggesting therapeutic potential.

Abstract

Honokiol activates SIRT3 and promotes deacetylation of the respiratory complex Ⅲ subunit CYC1, contributing to OXPHOS restoration and mitochondrial protection in AP. These findings suggest a previously unrecognized SIRT3-CYC1 signaling axis underlying honokiol's mitochondrial protective effects in AP. Please cite this article as: Miao YF, Yao JQ, Peng Y, Bai D, Fan SH, Li HY, Jin W, Lu Y. Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation. J Integr Med. 2026; Epub ahead of print.

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Cite This Study

Miao et al. (2026) studied this question.

synapsesocial.com/papers/69a75ce7c6e9836116a262be https://doi.org/10.1016/j.joim.2026.01.007

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Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Honokiol protects against acute pancreatitis by activating SIRT3 to restore mitochondrial oxidative phosphorylation and alleviate hyperacetylation

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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