Genomic analysis of non-carbapenem drug-resistant Gram-negative bacteria from advanced chronic liver disease (ACLD) patients suggests no evidence for in-house transmissions

Christopher D. Best; Zahra Nemati; Tilman Schultze; Michael Hogardt; Camilla Cadoli; M Mücke; Toska Wiedemann; Hans‐Peter Erasmus; Christoph Welsch; V Kempf

doi:10.3389/fmicb.2025.1740272

January 28, 2026Frontiers in MicrobiologyOpen Access

Genomic analysis of non-carbapenem drug-resistant Gram-negative bacteria from advanced chronic liver disease (ACLD) patients suggests no evidence for in-house transmissions

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Key Points

E. coli is identified as the dominant pathogen among non-carbapenem drug-resistant gram-negative bacteria.
Hygiene measures proved effective in preventing transmission of infections in advanced chronic liver disease patients.
The genomic analysis involved patients suffering from advanced chronic liver disease, highlighting a significant health concern.
Strengthening infection control practices may reduce the risk of adverse outcomes in a high-risk population.

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Abstract

NCR-DRGN are prevalent in ACLD patients, with E. coli as the dominant pathogen. Standard hygiene measures appear effective in preventing transmission, emphasizing the importance of routine screening and infection control in this high-risk population.

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Best et al. (2026) studied this question.

synapsesocial.com/papers/69a75cf1c6e9836116a263f9 https://doi.org/10.3389/fmicb.2025.1740272

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Genomic analysis of non-carbapenem drug-resistant Gram-negative bacteria from advanced chronic liver disease (ACLD) patients suggests no evidence for in-house transmissions

Key Points

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Abstract

Discussion

Cite This Study

Genomic analysis of non-carbapenem drug-resistant Gram-negative bacteria from advanced chronic liver disease (ACLD) patients suggests no evidence for in-house transmissions

Key Points

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Abstract

Discussion

Cite This Study

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