Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults

Malte Schmücker; Cathrine Tranberg; Jacob Borch; Mette Killerup Kaae; Michelle Damgaard; Mathias Flensted-Jensen; Ida Blom; Marco Morosetti; Sara Barbarossa; Patrick Orlando; Luca Tiano; Flemming Dela; Jørn Wulff Helge; Steen Larsen

doi:10.1007/s11357-025-02068-9

January 28, 2026GeroScience

Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults

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Key Points

Plasma levels of coenzyme Q10 increased significantly after supplementation, but mitochondrial function remained unchanged.
Participants saw a notable rise in coenzyme Q10 levels, but the expected improvements in mitochondrial operations did not occur.
This analysis involved older adults taking coenzyme Q10 supplements, evaluating both plasma levels and mitochondrial activity.
These findings indicate that while supplementation raises coenzyme Q10 in plasma, it may not impact mitochondrial health significantly.

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Implication

Observational analysis shows elevated plasma coenzyme Q10 levels without enhanced mitochondrial function in older adults, suggesting limits of supplementation effects.

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Schmücker et al. (2026) studied this question.

synapsesocial.com/papers/69a75cf6c6e9836116a26496 https://doi.org/10.1007/s11357-025-02068-9

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Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults

Key Points

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Implication

Discussion

Cite This Study

Coenzyme Q10 supplementation raises plasma levels without improving mitochondrial function in older adults

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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