Association of CYP2C19 gene single nucleotide polymorphisms (rs12248560 and rs4244285) with response to thalidomide in transfusion dependent β-thalassemia patients- a 12-months follow-up study

Inayat Ur Rahman; Maryam Shahid; Muhammad Tariq Humayun Khan; Naseer Ahmed; Shafiq Ahmad; Amir Muhammad; Sher Afghan Khan; Abdus Saboor; Muhammad Tariq Masood Khan; Sami Siraj

doi:10.1080/14622416.2026.2622318

December 12, 2025PharmacogenomicsOpen Access

Association of CYP2C19 gene single nucleotide polymorphisms (rs12248560 and rs4244285) with response to thalidomide in transfusion dependent β-thalassemia patients- a 12-months follow-up study

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Key Points

Thalidomide shows effectiveness in improving treatment response for transfusion dependent β-thalassemia patients.
CYP2C19 gene variants rs12248560 and rs4244285 are linked to the treatment outcomes observed in these patients.
Follow-up study conducted over 12 months provides insights into genetic influences on therapy effectiveness.
Individualized treatment may enhance outcomes, highlighting the importance of genetic testing for therapy optimization.

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Implication

Observational analysis reveals CYP2C19 genetic variation affects thalidomide response in β-thalassemia patients, suggesting personalized treatment approaches.

Abstract

The findings suggest thalidomide as an effective option for TDT and highlight the potential role of CYP2C19 genetic variation in modulating treatment response.

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Rahman et al. (2025) studied this question.

synapsesocial.com/papers/69a75d44c6e9836116a2702c https://doi.org/10.1080/14622416.2026.2622318

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Association of CYP2C19 gene single nucleotide polymorphisms (rs12248560 and rs4244285) with response to thalidomide in transfusion dependent β-thalassemia patients- a 12-months follow-up study

Key Points

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Implication

Abstract

Discussion

Cite This Study

Association of CYP2C19 gene single nucleotide polymorphisms (rs12248560 and rs4244285) with response to thalidomide in transfusion dependent β-thalassemia patients- a 12-months follow-up study

Key Points

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Implication

Abstract

Discussion

Cite This Study

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