Why the study?
Do trajectories of cognitive decline or persistently low cognitive function increase the risk of all-cause mortality in middle-aged and older adults with cardiovascular disease?
Do trajectories of cognitive decline or persistently low cognitive function increase the risk of all-cause mortality in middle-aged and older adults with cardiovascular disease?
Trajectories of rapid cognitive decline or persistently low cognitive function independently predict an increased risk of all-cause mortality in middle-aged and older adults with cardiovascular disease.
May warrant dynamic cognitive monitoring for risk stratification in CVD; extends prior findings to this population.
Among middle-aged and older adults with CVD, trajectories characterized by rapid cognitive decline or persistently low function are powerful, independent predictors of all-cause mortality. In contrast, cognitive improvement is not associated with excess mortality risk. These findings underscore the prognostic importance of dynamic cognitive assessment and suggest that monitoring cognitive trajectories may aid in the risk stratification of CVD patients.
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Di et al. (2026) studied this question.
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