METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells

Xianzhen Zeng; Xinyu Wang; Jiao Wang; Rui Zheng; Y Zhang; Tonggang Li; Jia Ma; Xueshan Pan

doi:10.21037/tcr-2025-2002

January 1, 2026Translational Cancer ResearchOpen Access

METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells

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Key Points

Astaxanthin significantly inhibits colorectal cancer cell growth, impacting treatment potential.
Key evidence demonstrated a relationship between METTL16 and ferroptosis in astaxanthin-treated cells.
Assessment reveals astaxanthin's effects on CRC and its mechanism via METTL16 modulation.
Highlights the importance of understanding ferroptosis in the context of colorectal cancer therapies.

Abstract

This study demonstrates that astaxanthin inhibits CRC cell growth and delineates its relationship and mechanisms with METTL16 and ferroptosis, providing a new direction for CRC treatment.

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Cite This Study

Zeng et al. (2026) studied this question.

synapsesocial.com/papers/69a75d68c6e9836116a276ee https://doi.org/10.21037/tcr-2025-2002

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METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells

Key Points

Abstract

Discussion

Cite This Study

METTL16 antagonizes astaxanthin-induced ferroptosis in colorectal cancer cells

Key Points

Abstract

Discussion

Cite This Study

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Keep reading

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