TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy

Farheen S. Shaikh; Meena Afroze Shanta; Anil K. Singh; Alexis Daniels; Sadik Khuder; Geoffrey M. Thiele; George Reed; Joel M. Kremer; Dimitrios A. Pappas; Jeffrey R. Curtis; James R. O’Dell; Ouseph MM; David A. Fox; Salahuddin Ahmed

doi:10.1038/s41423-026-01386-y

January 30, 2026Cellular and Molecular ImmunologyOpen Access

TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy

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Key Points

Inflammation is exacerbated in rheumatoid arthritis due to the tweak receptor Fn14's role in enhancing TNF-α effects.
Key evidence shows that TNF-α levels were significantly elevated in fibroblasts that express Fn14.
Assessment includes analyzing the inflammatory response and potential outcomes of anti-TNF-α therapies in synovial fibroblasts.
Findings underscore the need for personalized approaches in anti-TNF-α therapy due to the influence of Fn14.

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Implication

Observational analysis reveals Fn14 exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts, highlighting potential therapy implications.

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Shaikh et al. (2026) studied this question.

synapsesocial.com/papers/69a75d78c6e9836116a278f4 https://doi.org/10.1038/s41423-026-01386-y

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TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

TWEAK receptor (Fn14) exacerbates TNF-α-induced inflammation in rheumatoid arthritis synovial fibroblasts and influences response to anti-TNF-α therapy

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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