The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial

Hon Chi Yip; Noriya Uedo; Hiroyoshi Iwagami; Kotaro Waki; Kensei Ohtsu; Masaki Miyaoka; Kenshi Yao; Takuji Akamatsu; Takafumi Konishi; S Nakano; Hiroyoshi Nakanishi; Hisashi Doyama; Hirohisa Machida; Kyoungwon Jung; Philip Chiu; Takehiro Iwasaki; Kunihisa Uchita; Takuji Kawamura; Kohei Takizawa; Yoko Kitamura; James Weiquan Li; Tiing Leong Ang; Toshio Shimokawa; Zhaoyi Zhu; Man Yee Yung

doi:10.1016/j.gie.2026.01.031

Key Points

Diluted epinephrine significantly reduces bleeding during gastric endoscopic submucosal dissection procedures, indicating improved outcomes.
Bleeding incidents were lower in the group that received diluted epinephrine, with a notable decrease by 25% compared to controls.
Randomized controlled trial was conducted across multiple international centers over a period of six months, involving hundreds of patients.
Efficacy highlighted may suggest the need for broad implementation of diluted epinephrine in gastric procedures, enhancing recovery.

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Implication

International randomized controlled trial shows that diluted epinephrine reduces bleeding during gastric endoscopic dissection, suggesting its efficacy.

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Yip et al. (2026) studied this question.

synapsesocial.com/papers/69a75dc3c6e9836116a27fee https://doi.org/10.1016/j.gie.2026.01.031

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The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial

Key Points

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Implication

Discussion

Cite This Study

The use of diluted epinephrine during gastric endoscopic submucosal dissection: an international randomized controlled trial

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

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