Keratinization-related gene signature predicting survival and response to radiation in patients with HPV-negative head and neck squamous cell carcinoma via regulation of cornification and integrin signaling | Synapse
March 3, 2026Open Access
Keratinization-related gene signature predicting survival and response to radiation in patients with HPV-negative head and neck squamous cell carcinoma via regulation of cornification and integrin signaling
Key Points
Survival outcomes are significantly associated with keratinization-related gene signatures in HPV-negative patients.
Key evidence indicates a survival improvement for patients responding positively to radiation, with substantial gene expression variation.
Assessment using a unique gene signature reveals the role of cornification and integrin signaling pathways in radiation response.
Findings highlight the necessity for tailored therapeutic strategies based on keratinization-related profiles.