Metastatic organotropism in peritoneal metastasis: Paget’s hypothesis revisited

Dongchan Kim; Devesh Kaushal; Robert B. Wilson

doi:10.1007/s10238-025-01868-9

January 29, 2026Clinical and Experimental MedicineOpen Access

Metastatic organotropism in peritoneal metastasis: Paget’s hypothesis revisited

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Key Points

Peritoneal metastasis is influenced by organotropism, revealing patterns that align with Paget's hypothesis.
Key biological factors, including the tumor microenvironment, are critical in determining metastatic sites.
The analysis revisits Paget's hypothesis, suggesting a biological basis for preferential organ involvement in metastasis.
Understanding these mechanisms may enable more effective targeting strategies for metastatic cancers.

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Implication

Observational analysis reveals key factors influencing metastatic organotropism in peritoneal metastasis, suggesting new insights into treatment strategies.

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Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/69a75e17c6e9836116a2874b https://doi.org/10.1007/s10238-025-01868-9

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Metastatic organotropism in peritoneal metastasis: Paget’s hypothesis revisited

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Metastatic organotropism in peritoneal metastasis: Paget’s hypothesis revisited

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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