A Guide to Ex Vivo Biodistribution Studies with Radiotracers in Rodent Models

Key Points

• Biodistribution studies reveal the pathways radiotracers take within rodent models, enhancing our understanding of pharmacokinetics.
• In these studies, radiotracers help track how drugs move through biological systems, informing treatment strategies.
• Employing various imaging techniques allows for detailed examination of drug distribution over time in live rodent models.
• These findings highlight the importance of ex vivo studies for developing effective drug therapies, while also noting potential limitations.