Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins

Human M. Fatemi; Sahra Steinmacher; Laura Melado; Ibrahim Elkhatib; L. Marqueta; Francisco Ruiz; Raquel Del Gallego; Erkan Kalafat; Barbara Lawrenz

doi:10.3389/fendo.2026.1696657

January 29, 2026Frontiers in EndocrinologyOpen Access

Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins

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Key Points

Higher mature oocyte count is achieved with r-hFSH+r-hLH compared to HMG, indicating better IVF success.
Significantly more euploid blastocysts are produced using r-hFSH+r-hLH, enhancing potential for healthy pregnancies.
Analysis focuses on women with a stimulation dosage of at least 300 IU of gonadotropins, ensuring a relevant population.
Findings suggest r-hFSH+r-hLH may be a better choice for women undergoing fertility treatments, emphasizing the need for optimized protocols.

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Implication

Comparison of r-hFSH+r-hLH and HMG shows greater oocyte yield in women with normal ovarian reserve, suggesting improved IVF outcomes.

Abstract

The use of r-hFSH+r-hLH is associated with a significantly higher mature oocyte and euploid blastocyst count compared to HMG and the effect was most pronounced in women with normal ovarian reserve.

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Fatemi et al. (2026) studied this question.

synapsesocial.com/papers/69a75e4ac6e9836116a28bc2 https://doi.org/10.3389/fendo.2026.1696657

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Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins

Key Points

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Implication

Abstract

Discussion

Cite This Study

Optimizing mature oocyte yield in IVF: clinical comparison of r-hFSH+r-hLH and HMG in women with a stimulation dosage of at least 300 IU of gonadotropins

Key Points

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Implication

Abstract

Discussion

Cite This Study

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