Targeting PKC/NF-κB/NLRP3-driven NcRNA neuroinflammatory crosstalk by condensed tannins in global cerebral ischemia

Key Points

• PKC/NF-κB/NLRP3 signaling pathways are critical in neuroinflammation during global cerebral ischemia, influencing recovery.
• Analysis highlights that condensed tannins reduce neuroinflammatory responses significantly, suggesting a protective role.
• Experimentation focused on both in vitro and in vivo approaches to assess the mechanisms of action for condensed tannins.
• Findings suggest potential for novel therapeutic strategies in addressing neuroinflammation associated with ischemic events.