Inhibition of SUV39H1 and SUV39H2 promotes zygotic genome activation and improves the developmental competence of porcine somatic cell nuclear transfer embryos

Key Points

• Zygotic genome activation is significantly promoted by inhibiting SUV39H1 and SUV39H2, improving developmental competence.
• Inhibition of both genes leads to higher-quality embryos in somatic cell nuclear transfer techniques.
• Observational analysis shows that embryos with inhibited SUV39H1 and SUV39H2 exhibited better growth and viability.
• This highlights potential advancements in cloning methods, with implications for agricultural biotechnology.