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Case-control study finds tongue features may relate to cancer, suggesting further validation is needed.
Selected tongue features, particularly spider sublingual veins and tooth marks, were associated with current cancer in exploratory analyses. However, discrimination was modest, and inter-rater reliability varied across features. These findings should be interpreted cautiously and do not support diagnostic utility. Standardized definitions, rater training, and external validation in larger prospective, multi-center cohorts are required before clinical translation.
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Wu et al. (2026) studied this question.
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