Key result
Anti-VEGF therapy is linked to ~76% higher VTE risk in advanced NSCLC.
Why the study?
Non-small cell lung cancer is associated with a high risk of venous thromboembolism, but data on specific risk factors in advanced NSCLC remain limited.
Cohort (n=20,206)
Yes
Hazard Ratio: 1.763 (95% CI 1.458–2.132)
p-value: p=<0.001
Previous VTE, anti-VEGF therapy, heart failure, stroke/TIA, and platinum-based chemotherapy are significant risk factors for VTE in patients with advanced NSCLC, highlighting the need for risk-stratified monitoring.
Anti-VEGF use was associated with higher VTE risk in advanced NSCLC; leaves open need for risk-stratified prophylaxis trials.
Background: Non-small cell lung cancer (NSCLC) is associated with a high risk of venous thromboembolism (VTE). However, data on specific risk factors for VTE in patients with advanced NSCLC remain limited. Methods and Results: increase; 95% CI 1.009-1.048), previous VTE (HR 2.707; 95% CI 1.907-3.843), platinum-based chemotherapy (HR 1.217; 95% CI 1.051-1.410), anti-vascular endothelial growth factor agent (HR 1.763; 95% CI 1.458-2.132), heart failure (HR 1.677; 95% CI 1.432-1.965), and stroke/transient ischemic attack (HR 1.296; 95% CI 1.055-1.593). Conclusions: This large-scale study identified several significant risk factors for VTE in patients with advanced NSCLC. The findings suggest the need for risk-stratified monitoring and prophylactic strategies to reduce VTE-related complications in high-risk patients.
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Kimura et al. (2026) conducted a cohort in Advanced non-small cell lung cancer (NSCLC) (n=20,206). Anti-vascular endothelial growth factor (VEGF) agents vs. No anti-VEGF agents was evaluated on Incidence of venous thromboembolism (VTE) (HR 1.763, 95% CI 1.458-2.132, p=<0.001). Anti-VEGF agents significantly increased the risk of venous thromboembolism (HR 1.763) in patients with advanced non-small cell lung cancer, alongside other factors like previous VTE and heart failure.
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