In this study, selenium nanoparticles (SeNPs) decorated with lotus root polysaccharide (LR) were successfully synthesized, and the formation, particle size, morphology and stabilization of LR/SeNPs1-5 with different Se content were comprehensively characterized. The findings revealed that LR/SeNPs exhibited uniformly spherical nanoparticles with particle size of approximately 100 nm. FT-IR and XPS spectra showed that the stability of LR/SeNPs was attributed to the formation of C-O⋯Se coordination bonds and hydrogen bond networks between LR and SeNPs. And the environmental stability experiment has proved that LR/SeNPs3 exhibit excellent stability in normal temperature, neutral and low-salt environments, howerer, to maintain long-term stability, it is necessary to avoid from high temperatures, high acidity and high salt environments. Also, the modification of the SeNPs with LR granted the LR/SeNPs excellent anti-inflammatory capability, that decreased the level of NO, IL-1β and TNF-α, and promoted macrophage toward the M2 phenotype polarization, during which LR showed a synergistic effect. These results suggest that LR can not only enhance the stability of SeNPs, but also improve the anti-inflammatory activity of SeNPs, thereby functioning as a promising stabilizing agent for SeNPs.
Sun et al. (Thu,) studied this question.