Genotoxicity in oral mucosal cells associated with e-cigarette use: a systematic review and meta-analysis

Key Points

• Increased DNA damage is observed in oral mucosal cells of e-cigarette users compared to nonsmokers, indicating potential risks.
• The systematic review highlights that e-cigarettes induce less genotoxicity than conventional smoking overall, with specific concerns for DNA damage.
• Analysis involved reviewing multiple studies under standardized protocols, focusing on the genotoxic effects of e-cigarettes compared to traditional cigarettes.
• The findings suggest a need for more rigorous prospective studies to understand the long-term impacts of e-cigarette use on DNA integrity.