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Multi-layer analysis links EZH2 to immunosuppressive features in advanced prostate cancer, suggesting potential therapeutic targets.
This multi-layer integrative analysis suggests that EZH2 is associated with proliferative malignant states and immunosuppressive microenvironment features in advanced PCa, including Treg-linked crosstalk. Transcriptomic profiling following EZH2 inhibition supports modulation of these programs by EZH2-targeted perturbation, while functional and causal mechanisms warrant further investigation.
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Xiong et al. (2026) studied this question.
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