Pregnancy loss history is associated with both quantitative and qualitative alterations in immune senescence profiles, including organizational remodeling of peripheral immune senescence. Analysis of proinflammatory and regulatory T-cell subsets revealed additional associations, suggesting immune senescence may interact with adaptive immune polarization in early pregnancy. These findings highlight disrupted immune senescence as a potential component of immune maladaptation and identify senescent immune cells as candidate biomarkers for recurrent miscarriage.
Parvanov et al. (Wed,) studied this question.