SIRT3 attenuates chronic pain-induced depressive-like behaviors by deacetylating CypD at lysine 166 in central amygdala

Key Points

• SIRT3 attenuates depressive-like behaviors linked to chronic pain, supporting its therapeutic role.
• Key evidence shows that deacetylation of CypD at lysine 166 is crucial for SIRT3's effect.
• Analysis included use of animal models to understand SIRT3's influence on the central amygdala.
• Findings highlight the potential for targeting SIRT3 in treating depression related to chronic pain.