Single Center phase 1b Study of Orca-T Following Escalated Doses of Total Marrow and Lymphoid Irradiation (TMLI) in Patients with Acute Leukemia or MDS

Key Points

• Orca-T treatment shows promising efficacy in treating acute leukemia.
• Patients receiving escalated doses of total marrow lymphoid irradiation reported significant improvement in response rates.
• Observational analysis across patients undergoing Orca-T therapy reveals heightened efficacy compared to standard approaches.
• These findings suggest a potential new pathway for effective management of acute leukemia and MDS.