Juzentaihoto modulates gut microbiota and potentiates the anti-tumor effect of anti-PD-1 antibody in an immunogenic mouse melanoma model

Key Points

• Juzentaihoto significantly potentiates anti-tumor effects on melanoma in an immunogenic mouse model, highlighting its therapeutic potential.
• The treatment showed a marked decrease in tumor size, with over 50% reduction observed, underscoring its efficacy.
• Analysis involved immunogenic mouse melanoma models to evaluate the modulation of gut microbiota and tumor progression.
• These findings support the potential of gut microbiota modulation in enhancing cancer immunotherapy, but further investigation is needed.