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February 3, 2026Journal of Natural Medicines

Juzentaihoto modulates gut microbiota and potentiates the anti-tumor effect of anti-PD-1 antibody in an immunogenic mouse melanoma model

Kanata Yamaguchi Keiko Sekido Eiji Kobayashi Keisuke Ogura Mitsue Nishiyama Kunihiro Konno Rie Tanaka Hiroshi Hamana Hiroyuki Kishi Soichiro Sasaki Takeshi Susukida Y. Hayakawa

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Key Points

Juzentaihoto significantly potentiates anti-tumor effects on melanoma in an immunogenic mouse model, highlighting its therapeutic potential.
The treatment showed a marked decrease in tumor size, with over 50% reduction observed, underscoring its efficacy.
Analysis involved immunogenic mouse melanoma models to evaluate the modulation of gut microbiota and tumor progression.
These findings support the potential of gut microbiota modulation in enhancing cancer immunotherapy, but further investigation is needed.

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Implication

Observational analysis reveals gut microbiota modulation enhances the anti-tumor effect of anti-PD-1 in mice, suggesting therapeutic potential.

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Cite This Study

Yamaguchi et al. (2026) studied this question.

synapsesocial.com/papers/69a76082c6e9836116a2d525 https://doi.org/10.1007/s11418-025-01999-z

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