What question did this study set out to answer?

To determine how gut microbiome composition influences primary resistance and clinical efficacy during PD-1/PD-L1 blockade in patients with advanced epithelial tumors.

November 2, 2017Science

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

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Authors

BRBertrand RoutyHEC Montréal ECEmmanuelle Le ChatelierUniversité Paris-Saclay LDLisa DerosaInserm

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Implication

Translational study reveals gut microbiota composition dictates PD-1 immunotherapy response in epithelial cancer, suggesting bacterial interventions may reverse primary treatment resistance.

Key Points

To determine how gut microbiome composition influences primary resistance and clinical efficacy during PD-1/PD-L1 blockade in patients with advanced epithelial tumors.
Evaluated the impact of antibiotic treatment on clinical outcomes in patients with advanced cancer receiving immune checkpoint inhibitors.
Profiled patient stool samples at diagnosis using metagenomics to identify bacterial taxa associated with treatment response.
Transplanted responder or nonresponder patient feces into germ-free or antibiotic-treated mice receiving PD-1 blockade, followed by oral supplementation with Akkermansia muciniphila.
Antibiotic exposure significantly impaired the clinical efficacy of immune checkpoint inhibitors in patients with advanced cancer.
Fecal microbiota transplantation from responding patients into mice enhanced the antitumor efficacy of PD-1 blockade, whereas transplantation from nonresponders failed to do so.
Abundance of Akkermansia muciniphila correlated with clinical response, and oral supplementation with A. muciniphila restored PD-1 blockade efficacy in mice via an interleukin-12-dependent recruitment of CCR9+CXCR3+CD4+ T cells into tumors.

Cite This Study

Routy et al. (2017) studied this question.

synapsesocial.com/papers/69c32f9941e67842630cf87f https://doi.org/10.1126/science.aan3706

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Implication

Translational study reveals gut microbiota composition dictates PD-1 immunotherapy response in epithelial cancer, suggesting bacterial interventions may reverse primary treatment resistance.

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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