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March 3, 2026Molecular and Clinical OncologyOpen Access

5‑ALA vs. fluorescein guided resection for high‑grade gliomas: A systematic review and meta‑analysis

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Authors

EKEvangelos KogiasGFGeorge FotakopoulosVGVasiliki Georgakopoulou

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Overview

Meta-analysis compares 5-ALA and fluorescence-guided surgery outcomes in high-grade gliomas, highlighting potential benefits of 5-ALA.

Key Points

  • 5-ALA-guided resection is linked to lower postoperative neurological deficits and better overall survival outcomes.
  • The meta-analysis included 41 studies, involving 732 patients, comparing 5-ALA to alternative FGS techniques.
  • Systematic literature search focused on 5-ALA and other fluorescence-guided approaches in high-grade glioma management.
  • Findings suggest the need for more high-quality trials due to publication bias and data heterogeneity.

Cite This Study

Kogias et al. (2026) studied this question.

synapsesocial.com/papers/69a760d6c6e9836116a2df77https://doi.org/10.3892/mco.2026.2927
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