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March 3, 2026Molecular and Clinical OncologyOpen Access

Expression and significance analyses of microRNAs in colorectal cancer

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Authors

JZJing ZhangLSLiwei SunCYChangxiu Yan

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Overview

Observed associations of microRNAs with colorectal cancer progression, suggesting their potential as therapeutic targets.

Key Points

  • MicroRNAs miR-205, miR-376c, and miR-539 are significantly involved in colorectal cancer development and prognosis.
  • In the GSE41655 dataset, miR-376c had the most pronounced downregulation in tumor tissues compared to normal tissues.
  • Analysis of clinical data from 25 patients revealed significant differences based on tumor stage and lymph node metastasis.
  • MiR-376c is notably associated with CRC liver metastasis, indicating its importance in cancer progression.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a76812badf0bb9e87e37cfhttps://doi.org/10.3892/mco.2026.2929
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