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March 3, 2026Molecular and Clinical OncologyOpen Access

Sequential immune checkpoint inhibition after palliative radiotherapy in patients with advanced head and neck squamous cell carcinoma: A retrospective cohort study

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Authors

AKAtsuto KatanoAOAkiko OkaMMMasanari Minamitani

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Overview

Retrospective cohort study evaluates survival outcomes of ICI therapy after RT in HNSCC, suggesting improved effectiveness.

Key Points

  • RT-ICI group achieved a 2-year overall survival rate of 55.8%, compared to 5.7% in the RT group, indicating significant treatment benefit.
  • Multivariate analysis identified RT-ICI treatment as an independent predictor of overall survival with a hazard ratio of 0.22.
  • Palliative radiotherapy with higher biologically effective doses (≥39 Gy) is linked to better overall survival outcomes in patients.
  • Sequential therapy presents safety concerns, as 17.6% of patients experienced grade 3 or higher immune-related adverse events.

Cite This Study

Katano et al. (2026) studied this question.

synapsesocial.com/papers/69a7687fbadf0bb9e87e4de0https://doi.org/10.3892/mco.2026.2931
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