Pharmacodynamic Analysis of AGAVE-201 Indicates Changes in CSF-1R–Expressing Cells and Associated Biomarkers Potentially Contributing to Chronic Graft-Versus-Host Disease Resolution

Michael A. Pratta; Angelina Volkova; Ian M. Catlett; Yan-ou Yang; Breann Barker; Song Lou; Chuan Tian; Xuecheng Zhang; Sophie Paczesny; Peter Ordentlich

doi:10.1016/j.jtct.2025.12.344

February 1, 2026Transplantation and Cellular Therapy

Pharmacodynamic Analysis of AGAVE-201 Indicates Changes in CSF-1R–Expressing Cells and Associated Biomarkers Potentially Contributing to Chronic Graft-Versus-Host Disease Resolution

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Key Points

Changes in CSF-1R-expressing cells correlate with biomarkers linked to chronic graft-versus-host disease resolution, indicating progress in understanding immune response.
Notable alterations in biomarkers were observed, including instances of improvement in 45% of evaluated patients' conditions linked to treatment implications.
Assessment using pharmacodynamic measures highlighted significant shifts in immune cell types, providing insights into mechanisms of action.
Further research is necessary to validate these findings and explore therapeutic strategies aimed at chronic graft-versus-host disease.

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Implication

Observational analysis reveals changes in CSF-1R-expressing cells and biomarkers in chronic graft-versus-host disease, suggesting implications for treatment.

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Pratta et al. (2026) studied this question.

synapsesocial.com/papers/69a760dec6e9836116a2e053 https://doi.org/10.1016/j.jtct.2025.12.344

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Pharmacodynamic Analysis of AGAVE-201 Indicates Changes in CSF-1R–Expressing Cells and Associated Biomarkers Potentially Contributing to Chronic Graft-Versus-Host Disease Resolution

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Implication

Discussion

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Pharmacodynamic Analysis of AGAVE-201 Indicates Changes in CSF-1R–Expressing Cells and Associated Biomarkers Potentially Contributing to Chronic Graft-Versus-Host Disease Resolution

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