Steroid Refractory GI Acute GVHD Is Associated with Distinct Immune Cell Infiltrates and Gene Expression Profiles

Key Points

• Steroid refractory GI acute graft-versus-host disease is associated with unique immune cell profiles, indicating underlying pathophysiology.
• Findings show specific gene expression profiles that may differentiate response types in GI acute graft-versus-host disease.
• Assessment of immune cell infiltrates highlights diverse immunological activity linked to poor steroid response patterns.
• Further investigation is needed to understand the clinical implications of these immune profiles in treatment decisions.