Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity by intervening in microtubule acetylation

Ruixue Yao; Jingyi Huang; Xiaoli Shan; Rongshan Li; Huihua Chen; Pei‐Ji Zhao; R Lu; Chen Zhang

doi:10.1016/j.jep.2026.121398

February 17, 2026Journal of Ethnopharmacology

Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity by intervening in microtubule acetylation

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Why the study?

Doxorubicin induces dose-dependent cardiotoxicity, but the potential efficacy of Guizhi Gancao Decoction against this cardiotoxicity remained unexplored.

Does Guizhi Gancao Decoction prevent doxorubicin-induced cardiotoxicity in mice and cardiomyocytes?

Key Points

Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity with a notable effect on microtubule acetylation.
Cardiotoxicity from doxorubicin administration is markedly reduced by using Guizhi Gancao Decoction, with evidence pointing to microtubule changes.
Assessment of cellular processes indicates a direct intervention in microtubule acetylation associated with Guizhi Gancao Decoction's protective role against doxorubicin.
This study highlights the potential of Guizhi Gancao Decoction as a protective intervention, where further clinical validation is necessary.

Structured PICO

Does Guizhi Gancao Decoction prevent doxorubicin-induced cardiotoxicity in mice and cardiomyocytes?

P

Population

Doxorubicin-induced cardiotoxicity models in vivo in mice and in vitro in cardiomyocytes

I

Intervention

Guizhi Gancao Decoction (GGD)

C

Comparator

Dexrazoxane (DEX), paclitaxel (TAX), and doxorubicin alone

O

Outcome

Cardiac structure and function, cardiomyocyte viability, α-tubulin acetylation, T-tubule integrity, and key protein expressionsurrogate

Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity by inhibiting HDAC6-mediated α-tubulin deacetylation, stabilizing microtubules and preserving calcium handling.

Implication

Should not change clinical practice; hypothesis-generating for HDAC6 inhibition in anthracycline cardiotoxicity.

Discussion

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Journal of Ethnopharmacology published a graphical abstract

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/69a7618ec6e9836116a2f933 https://doi.org/10.1016/j.jep.2026.121398

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Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity by intervening in microtubule acetylation

Key Points

Structured PICO

Implication

Discussion

Journal of Ethnopharmacology published a graphical abstract

Cite This Study

Guizhi Gancao Decoction protects against doxorubicin-induced cardiotoxicity by intervening in microtubule acetylation

Key Points

Structured PICO

Implication

Discussion

Journal of Ethnopharmacology published a graphical abstract

Cite This Study

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