MyCARdiac score: integrating cardiac imaging and biomarkers to predict outcomes in RRMM patients receiving cilta-cel

Figures

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  Fig. 1. I Association of echocardiographic and cardiac biomarkers with survival outcomes after Cilta-cel. Univariate Cox regression analyses of echocardiographic parameters and cardiac biomarkers with respect to progression-free survival (PFS, a) and overall survival (OS, b). Hazard ratios with 95% confidence intervals (95% CI) are shown. Raw p-values and false discovery rate (FDR)-adjusted p-values are reported, with statistical significance indicated by asterisks based on the adjusted p-values (p ≤ 0.05, p < 0.01). c–g Kaplan–Meier curves of PFS stratified by optimized cut-off values for LVPWd, LVM-Index, LVEF, CAC, and NT-proBNP. h–l Kaplan–Meier curves of OS stratified by the same parameters. HR, 95% CI, and log-rank p-values are shown, and numbers at risk are indicated below each plot. m–q Box plots showing the associations of the same parameters with the occurrence of adverse cardiac events. The Mann–Whitney U test was used for statistical analysis, and statistical significance was defined as p < 0.05.

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  Fig. 2. Impact of the MyCARdiac score and cardiovascular risk on treatment outcomes. a Definition of the MyCARdiac score components and distribution of high-risk patients. b Correlation matrix of echocardiographic parameters and cardiac biomarkers. c–f Baseline associations of MyCARdiac risk status with sBCMA, EMD, log2(EASIX), and R-ISS stage. g, h Post-infusion sBCMA and IL-6 levels by risk group. i–l Distribution of early and late N-ICAHT and T-ICAHT scores. m, n Association of MyCARdiac risk with treatment response and CRS grade. o–t Expansion kinetics of total CD3+, CD4+, and CD8+ T-cells and CAR+ subsets stratified by risk. u, v Kaplan–Meier curves for PFS and OS according to MyCARdiac (blue) and HFO-ICOS (red) risk classification. HR, 95% CI, and log-rank p-values are shown, and numbers at risk are indicated below each plot. Statistical significance was defined as p < 0.05. Two (c, e, g, h) or one (o–t) sided Mann-Whitney U, chi-square (d, f, i–n), and log-rank (u, v) tests were applied when appropriate.