PF protects retinal pigment epithelial cells from oxidative injury by enhancing mitophagy through a CUL3-dependent AMPK/ULK1 pathway

Key Points

• PF significantly enhances mitophagy, reducing oxidative injury in retinal pigment epithelial cells, promoting cell survival.
• Key evidence indicates a robust upregulation of mitophagy markers, alongside improved cell viability under oxidative stress conditions.
• Analysis using a cellular model demonstrated the involvement of the CUL3-dependent AMPK/ULK1 signaling pathway in mediating PF effects.
• This work highlights the potential for PF as a protective agent against retinal damage, warranting further investigation in clinical applications.