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March 3, 2026World Journal of Gastrointestinal OncologyOpen Access

Microbiota-metabolite signatures in metastatic colorectal cancer: Promise, pitfalls, and the path forward

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Authors

TZTing-Ting ZhangJYJuan YaoHZHan-Meng Zhang

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Overview

Evaluation reveals microbiota and metabolites differ in metastatic colorectal cancer, indicating potential diagnostic targets.

Key Points

  • Metastatic colorectal cancer patients show significant differences in microbiota and metabolites compared to non-metastatic patients.
  • The study identified 91 differential metabolites related to nucleic acid, alkaloid, and lipid metabolism, highlighting their role in metastasis progression.
  • Analysis utilized 16S rRNA sequencing and metabolomics to explore microbial and metabolic changes in cancer.
  • Findings underscore the importance of integrating clinical data in future studies to validate the microbiota-metabolite axis.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69a76564badf0bb9e87d8f04https://doi.org/10.4251/wjgo.v18.i2.115010
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