This review summarizes how metallic elements influence gastric cancer pathogenesis and highlights new therapeutic options.
Key Points
Gastric cancer pathogenesis is significantly influenced by metallic elements like iron and copper, leading to diverse molecular mechanisms.
Iron overload triggers oxidative stress through the Fenton reaction, contributing to immune suppression.
Copper imbalance leads to mitochondrial dysfunction and cuproptosis, while zinc deficiency affects transcriptional regulation with detrimental effects.
Advancements in techniques like laser ablation inductively coupled plasma mass spectrometry enhance diagnostics and highlight potential for metal-based therapies.