Why the study?
The beneficial cardiovascular effects of regular physical activity may be linked to changes in plasma HDL levels, composition, and functional properties, motivating a review of its protective mechanisms.
Design
Review
Physical activity may be recommended to favorably modify HDL and mitigate cardiovascular risk; extends current models of exercise-mediated cardioprotection.
Numerous epidemiological studies have proven an inverse relationship between the content of high-density lipoprotein (HDL) in blood plasma and the risk of developing cardiovascular disease (CVD) of atherosclerotic genesis. On the other hand, it is well known that regular physical activity is an important component of the treatment of most CVDs and prevents the development of atherosclerosis. Thus, the beneficial effect of physical activity on the cardiovascular system can be largely associated with an increase in the level of plasma HDL under these conditions, changes in their composition and functional properties. The purpose of this review is to discuss possible mechanisms of the protective effect of HDL on the cardiovascular system during physical activity.
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Poteryaeva et al. (2025) studied this question.
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