March 3, 2026Open Access

Spontaneous association of different forms of non-conjugated astatine-211 to serum albumin

Key Points

Free astatine associates with serum albumin at a significantly higher level than iodine, improving its blood circulation time.
This notable association suggests potential implications for improving drug delivery systems using free astatine.
The investigation compares various forms of non-conjugated astatine specifically regarding their interaction with serum proteins.
Findings may extend current understanding of astatine's pharmacokinetics in therapeutic applications.

Abstract

Different forms of unbound astatine differ in their association to albumin. However, all investigated forms of free astatine associates to albumin to a much higher degree than iodine. This behavior could explain the prolonged blood circulation of free astatine compared to iodine.

Spontaneous association of different forms of non-conjugated astatine-211 to serum albumin

Key Points

Abstract

Cite This Study