Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency

Cui Jian; Colleen M. Roark; José Ferreres; P. Nozal Aranda; Begona Losada; Pilar Zamarrón; Jacob Lorenzo-Morales; José Miguel Rubio Muñoz; Megan Dobrose; Audrey Vincent; N. Amenzoui; Catherine L. Shelton; Dante Reyna; Janet Markle.; Santiago Rodríguez de Córdoba; Mercedes Alba; Rebeca Perez de Diego; C. Henrique Serezani; Mariana X. Byndloss; Isabel de Fuentes Corripio; Luis Ignacio Gonzalez-Granado; Rubén Martínez Barricarte

doi:10.64898/2026.01.31.26345168

Key Points

PAM can be caused by complement C2 deficiency, with significant clinical implications for immune health.
The study identifies a specific immunological error related to the complement system that increases susceptibility.
Understanding this connection helps to clarify the role of immune pathways in fighting Naegleria fowleri infections.
Further research is needed to explore additional genetic factors contributing to similar immune deficiencies.

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Implication

Observational analysis reveals PAM is linked to complement C2 deficiency in patients, indicating critical immune vulnerabilities.

Abstract

Our study demonstrates that PAM can be caused by a monogenic inborn error of immunity (IEI) and that the complement system is critical for human immunity against Naegleria fowleri.

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Cite This Study

Jian et al. (2026) studied this question.

synapsesocial.com/papers/69a76629badf0bb9e87dbf3c https://doi.org/10.64898/2026.01.31.26345168

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Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency

Key Points

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Implication

Abstract

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Cite This Study

Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency

Key Points

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Implication

Abstract

Discussion

Cite This Study

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