The effects of Kai-Xin-San in alleviating chronic social defeat stress-induced depression-like behaviors are associated with CD4+ T cells

Key Points

• Kai-Xin-San significantly reduces depression-like behaviors associated with chronic stress.
• In a comparison, CD4+ T cell modulation was correlated with improved outcomes, revealing a notable link.
• Assessment involved chronic social defeat stress models to explore neuroinflammation effects on behavior.
• These findings highlight the role of immune response in treating chronic stress-related issues, indicating potential therapeutic avenues.