SPHK1 deficiency promotes intestinal homeostasis by ameliorating ER stress-induced gastrointestinal injury during murine graft-versus-host disease

Key Points

• Sphk1 deficiency significantly reduces gastrointestinal injury during graft-versus-host disease—indicating its protective role.
• Key evidence shows that sphk1 deficiency leads to improved intestinal homeostasis under ER stress conditions.
• Analysis of murine models during graft-versus-host disease highlights the impact of sphk1 deficiency on gastrointestinal health.
• This study suggests potential therapeutic avenues in managing gastrointestinal injury in graft-versus-host disease.