Mice from lines selectively bred for innately high activity levels have altered behavioral and energetic responses to repeated sleep deprivation

Key Points

• Behavioral and energetic responses were significantly altered after repeated sleep deprivation in high-activity mice.
• Sleep deprivation caused notable changes in movement and energy use, with activity levels affected across trials.
• Observational analysis of selectively bred mice for high activity levels helped uncover these unique responses.
• These findings may inform how selective breeding impacts adaptive behaviors and energy metabolism under stress.