Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices

Phani Sudarsanam; Ralph J. S. van Mechelen; Tim J.M. Kuijpers; Christian J.F. Bertens; Els Alsema; Juul Verbakel; Nick R.M. Beijer; Henny J. M. Beckers; Jan de Boer

doi:10.1016/j.bioactmat.2026.01.012

February 2, 2026Bioactive MaterialsOpen Access

Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices

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Key Points

Myofibroblast differentiation is significantly affected by immunomodulatory topographies, which can alter fibrous encapsulation.
The study observes an increase in encapsulation issues related to drainage devices under specific topographical conditions.
Observational analysis explores how different topographies regulate myofibroblast behavior in the context of glaucoma drainage devices.
Findings support the need for innovative device design to mitigate adverse encapsulation effects, enhancing treatment efficacy.

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Implication

Observational analysis shows myofibroblast differentiation influenced by immunomodulatory topographies, suggesting new strategies for glaucoma treatments.

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Cite This Study

Sudarsanam et al. (2026) studied this question.

synapsesocial.com/papers/69a7668fbadf0bb9e87dd74a https://doi.org/10.1016/j.bioactmat.2026.01.012

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Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices

Key Points

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Implication

Discussion

Cite This Study

Immunomodulatory topographies regulate myofibroblast differentiation and influence fibrous encapsulation of glaucoma drainage devices

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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