March 3, 2026Frontiers in PhysiologyOpen Access

Association between ALDH2 rs671 polymorphism and susceptibility to non-valvular atrial fibrillation in a Chinese population: a large-scale case–control study

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Why the study?

Oxidative stress drives atrial remodeling and mitochondrial ALDH2 detoxifies reactive aldehydes, but the association of the ALDH2 rs671 polymorphism with non-valvular atrial fibrillation needed examination in an East Asian population.

Does the ALDH2 rs671 polymorphism increase the risk of non-valvular atrial fibrillation in a Chinese population?

Population

403 NVAF patients and 14,326 hospitalized controls aged ≥30 years in China

Comparison

ALDH2 rs671 polymorphism variants vs controls

Design

Retrospective propensity score-matched case-control study

Authors

FZFangming ZhongMeizhou City People's Hospital QZQifeng ZhangMeizhou City People's Hospital ZYZhuolian YeMeizhou City People's Hospital

Discussion

Member takes

Implication

Should not yet inform NVAF risk stratification in Chinese patients; extends ALDH2 rs671 association data but remains hypothesis-generating.

Key Points

Increased NVAF risk was linked to the ALDH2 rs671 A allele frequency, which was higher in patients than in controls.
The odds ratio for individuals with the GA genotype was 1.681, representing a significant genetic risk factor for NVAF in this population.
Retrospective analysis included 403 NVAF patients and 14,326 controls while employing logistic regression for adjusted assessments.
Findings highlight the importance of this polymorphism as an independent risk factor alongside age, sex, and other cardiovascular conditions.

Structured PICO

Does the ALDH2 rs671 polymorphism increase the risk of non-valvular atrial fibrillation in a Chinese population?

Population

14,729 hospitalized patients aged ≥30 years from a Chinese population (Meizhou People's Hospital, 2016-2020), comprising 403 patients with non-valvular atrial fibrillation (NVAF) and 14,326 controls.

Intervention

Presence of ALDH2 rs671 polymorphism (A allele, GA or AA genotype)

Comparator

Absence of ALDH2 rs671 polymorphism (wild-type GG genotype)

Outcome

Susceptibility to/presence of non-valvular atrial fibrillation (NVAF)

The ALDH2 rs671 polymorphism is an independent genetic risk factor for non-valvular atrial fibrillation in the Chinese population.

Cite This Study

Zhong et al. (2026) studied this question.

synapsesocial.com/papers/69a7669bbadf0bb9e87ddab1 https://doi.org/10.3389/fphys.2025.1669815

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Implication

Should not yet inform NVAF risk stratification in Chinese patients; extends ALDH2 rs671 association data but remains hypothesis-generating.

Association between ALDH2 rs671 polymorphism and susceptibility to non-valvular atrial fibrillation in a Chinese population: a large-scale case–control study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Association between ALDH2 rs671 polymorphism and susceptibility to non-valvular atrial fibrillation in a Chinese population: a large-scale case–control study

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider