Extract We read with great interest the recent study by Khalaili et al. 1, which offers a timely multicentre comparison of early-onset (POBE) and adult-onset (AOBE) bronchiectasis across European and Middle Eastern populations. By delineating differences in presentation, microbiology and radiological features, the authors contribute valuable insights into age-related disease heterogeneity. However, several methodological limitations substantially limit the external validity and clinical applicability of these findings in broader, non-tertiary care settings.
Wu et al. (Sun,) studied this question.